ペルオキシソーム増殖薬活性化受容体（PPAR）研究の四半世紀—その盛衰の背景と教訓

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タイトル別名
  • Lessons Learned after 25 Years of Studies on the Physiological Roles of the Peroxisome Proliferator-activated Receptor
  • ペルオキシソーム増殖薬活性化受容体(PPAR)研究の四半世紀 : その盛衰の背景と教訓
  • ペルオキシソーム ゾウショクヤク カッセイカ ジュヨウタイ(PPAR)ケンキュウ ノ ヨン ハンセイキ : ソノ セイスイ ノ ハイケイ ト キョウクン

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説明

  The peroxisome proliferator-activated receptor (PPAR) was discovered a quarter of a century ago. PPAR was soon recognized as a general transcriptional regulator of lipid homeostasis, and several hypolipidemic and antidiabetic agents were shown to be effective ligands for it. Since then, many attempts to develop more potent drugs have been made worldwide, but most were unsuccessful due to serious side effects. It appears that the PPAR boom has ended. This review summarizes the short history of PPAR studies, including our own results, and discusses the lessons learned from the rise and fall of studies in this field for next-generation basic studies and drug development research.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 135 (10), 1083-1089, 2015-10-01

    公益社団法人 日本薬学会

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