Effect of Gallic Acid Derivatives on Secretion of Th1 Cytokines and Th2 Cytokines from Anti CD3-Stimulated Spleen Cells.

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  • KATO Kei
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University
  • YAMASHITA Shozo
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University
  • KITANAKA Susumu
    College of Pharmacy, Nihon University
  • TOYOSHIMA Satoshi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University

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Other Title
  • ヘルパーＴ細胞サブタイプ特異的サイトカイン分泌への没食子酸誘導体の影響
  • ヘルパー Tサイボウ サブタイプ トクイテキ サイトカイン ブンピ エ ノ ボッショクシサン ユウドウタイ ノ エイキョウ

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Description

As reported previously (Kosuge et al., Yakugaku Zasshi, 120, 408 (2000)), methyl gallate, a gallic acid derivative, which has been one of compounds isolated from extracts of Psidium geneus Myrtaceae, selectively suppresses Th2 cytokine secretion. In the present study, to examine more effective compounds than methyl gallate, the effects of various gallic acid derivatives on the secretion of helper T cell subtype specific cytokines from anti CD3-stimulated spleen cells were investigated. Ten μg/ml of methyl gallate and ethyl gallate remarkably suppressed the secretion of IL-4 and IL-5, Th2 cytokines, but did not suppress meaningfully the secretion of IFN-γ, a Th1 cytokine. On the other hand, the other gallic acid derivatives suppressed the secretion of both IL-4 and IFN-γ. Ten μg/ml of methyl gallate suppressed the secretion of IL-2, a Th1 cytokine, but the same concentration of ethyl gallate did not suppress it. In conclusion, it seemed that ethyl gallate was the most selective inhibitor for the secretion of Th2 cytokines among gallic acid derivatives used in this study.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 121 (6), 451-457, 2001

    The Pharmaceutical Society of Japan

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