Analysis of the Components of Porcine Liver Hydrolysate and Examination of the Antioxidant Activity and Angiotensin Converting Enzyme (ACE)-inhibiting Activity

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  • Inoue Naonori
    Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki Consumer Healthcare Laboratories, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
  • Hamasaki Atsuko
    Consumer Healthcare Laboratories, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
  • Hidaka Shuji
    Laboratory of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
  • Miura Naoyoshi
    Consumer Healthcare Laboratories, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
  • Fukahori Masahiro
    Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd.
  • Maruyama Masugi
    Department of Applied Physiology, Faculty of Medicine, University of Miyazaki
  • Kawahara Satoshi
    Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki Laboratory of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
  • Ohta Kazuyoshi
    Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki Laboratory of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
  • Muguruma Michio
    Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki Laboratory of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

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Other Title
  • ブタ肝臓水解物の成分分析と抗酸化活性及びアンギオテンシン変換酵素（ACE）阻害活性の検討
  • ブタ カンゾウ スイカイブツ ノ セイブン ブンセキ ト コウサンカ カッセイ オヨビ アンギオテンシン ヘンカン コウソ(ACE)ソガイ カッセイ ノ ケントウ

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Hypertension and oxidant stress predispose to the onset and progression of arteriosclerotic diseases. In this study, the components of two kinds of porcine liver hydrolysates (LH-I and LH-II) were analyzed, and the antioxidant effects and angiotensin converting enzyme (ACE)-inhibiting effects of LH-I and LH-II were examined in vitro. Furthermore, the effects of LH-I and LH-II on the blood pressure were examined in spontaneously hypertensive rats (SHR). The results showed that peptides and amino acids accounted for 70% or more of the constituents of both LH-I and LH-II. The results of gel filtration HPLC showed that most of the nitrogen-containing components were peptides or amino acids with molecular weights of 6000 or less. The DPPH radical scavenging activities of LH-I and LH-II were 55.6 and 38.1 μM Trolox Equivalent/g, respectively. The IC50 values for the ACE-inhibiting activity of LH-I and LH-II were 0.18 and 0.31 mg/mL, respectively. Oral administration of 1 g/rat of LH-I or LH-II to SHR resulted in significant lowering of the blood pressure. These findings indicate that both LH-I and LH-II have antioxidant activity and ACE-inhibiting activity. Moreover, both exerted a blood pressure-lowering effect in SHR. The antioxidant activity and ACE-inhibiting activity of LH-I and LH-II are presumed to be based on the actions of the component peptides.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 133 (1), 107-115, 2013

    The Pharmaceutical Society of Japan

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