書誌事項
- タイトル別名
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- Determination of Theophylline in Biological Fluids by High-Performance Liquid Chromatography
- コウソク エキタイ クロマトグラフホウ ニヨル タイエキチュウ ノ テオフィリ
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説明
High performance liquid chromatographic method for the determination of theophylline in biological fluids (serum, saliva and urine) was developed. Theophylline in biological fluids was adsorbed on a diatom earth column, followed by elution with a mixture of chloroform-isopropanol (95 : 5). After evaporation of the solvent, the residue was dissolved in water, injected onto a HPLC column packed with an ODS stationary phase eluted at 40°C with a mixture of 0.1M phosphate buffer (pH 5.3)-acetonitrile (9 : 1) and detected at 273 nm. 8-Chlorotheophylline was used as an internal standard. The recovery of theophylline from serum by this method was 100.1%±1.76% (SD ; n=5), Other xanthine derivatives (theobromine and caffeine) were seperated under the same conditions.
収録刊行物
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- 薬学雑誌
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薬学雑誌 101 (10), 955-959, 1981
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681105676032
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- NII論文ID
- 110003650087
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 2362357
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- データソース種別
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- JaLC
- NDL
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- 使用不可