Effects of Maltitol or Mannitol on Gastrointestinal Absorption of Drugs

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  • 薬物の消化管吸収におよぼすマルチトールおよびマンニトールの影響
  • ヤクブツ ノ ショウカカン キュウシュウ ニ オヨボス マルチトール オヨビ

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Abstract

Effects of maltitol and mannitol on the gastrointestinal absorption of acetaminophen, sulfisoxazole and riboflavine in mice were investigated. When drugs were orally administered with maltitol or mannitol, and 2 hr after maltitol or mannitol was orally given in mice (in diarrhea), the blood levels of drugs became lower than that in the control, and drug absorption was inhibited. It was suggested that these results were not caused by molecular interaction between drugs and sugar alcohols, but by the action of maltitol and mannitol which accelerated small intestinal motility, secretion and vascular permeability in the intestinal membrane. These changes may be mediated by biogenic amine, serotonin, histamine and polyamines in the small intestine.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 100 (11), 1118-1126, 1980

    The Pharmaceutical Society of Japan

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