The Effect of Physical Condition in Second Emulsification for Yield of Microcapsules
Bibliographic Information
- Other Title
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- マイクロカプセルの収率に対する二次乳化における物理的条件の効果
- マイクロカプセル ノ シュウリツ ニ タイスル ニジ ニュウカ ニ オケル ブ
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Description
Some physical and dynamical factors affecting the second emulsification were investigated in ethyl cellulose microcapsules containing aspirin prepared by a multiple (WI/O/WII) emulsion method. Furthermore, the dissolution rates of aspirin from microcapsules were measured. The following results were obtained ; In the second emulsification at preparation, the mean length diameter of microcapsules decreased initially and was leveled off later with an increase in the gelatin concentration in outer aqueous phase. The yield of microcapsules decreased as the revolution number of agitation became higher. The change in the serum concentration of aspirin after administration of aspirin microcapsules was apparently different from the plain powder, showing delayed release properties at the early time periods and a flatter response decay at the later time periods.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 100 (12), 1209-1214, 1980
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282681106173440
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- NII Article ID
- 110003650736
- 130007275102
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 2340860
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed