マイクロカプセルの収率に対する二次乳化における物理的条件の効果

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書誌事項

タイトル別名
  • The Effect of Physical Condition in Second Emulsification for Yield of Microcapsules
  • マイクロカプセル ノ シュウリツ ニ タイスル ニジ ニュウカ ニ オケル ブ

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説明

Some physical and dynamical factors affecting the second emulsification were investigated in ethyl cellulose microcapsules containing aspirin prepared by a multiple (WI/O/WII) emulsion method. Furthermore, the dissolution rates of aspirin from microcapsules were measured. The following results were obtained ; In the second emulsification at preparation, the mean length diameter of microcapsules decreased initially and was leveled off later with an increase in the gelatin concentration in outer aqueous phase. The yield of microcapsules decreased as the revolution number of agitation became higher. The change in the serum concentration of aspirin after administration of aspirin microcapsules was apparently different from the plain powder, showing delayed release properties at the early time periods and a flatter response decay at the later time periods.

収録刊行物

  • 薬学雑誌

    薬学雑誌 100 (12), 1209-1214, 1980

    公益社団法人 日本薬学会

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