クマリン誘導体の合成研究 (第9報)

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書誌事項

タイトル別名
  • Studies on the Syntheses of Coumarin Derivatives. IX
  • クマリン-3-カルボン酸誘導体の生体内変化について
  • On the Metabolic Change of Coumarin-3-carboxylic Acid Derivatives

説明

Ethyl 7-nitrocoumarin-3-carboxylate and ethyl coumarin-3-carboxylate were each injected into a mouse or applied on excised liver and kidney of a mouse and the fluorescent substance found in the urine, liver, and kidneys was examined by paper chromatography. The results shown in Tables I, II, and IV, suggested the in vitro change of these compounds to be as follows:<br>1) Ethyl 7-nitrocoumarin-3-carboxylate is chiefly reduced in the liver and the kidney and hydrolyzed at the same time to 7-aminocoumarin-3-carboxylic acid. A part of it is further acetylated in the liver to the 7-acetylamino derivative, these two substances being excreted in the urine.<br>2) Ethyl coumarin-3-carboxylate undergoes hydrolysis and other changes in the liver and a part of it changes to coumarin-3-carboxylic acid.

収録刊行物

  • 薬学雑誌

    薬学雑誌 75 (12), 1489-1491, 1955

    公益社団法人 日本薬学会

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