Quantitative Analysis and Pharmaco-Toxicity of Cannabinoids in Commercially Available Cannabis Seeds
Bibliographic Information
- Other Title
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- 市販の大麻種子中のカンナビノイドの定量とその薬毒理作用
- シハン ノ タイマ シュシ チュウ ノ カンナビノイド ノ テイリョウ ト ソ
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Abstract
△9-Tetrahydrocannabinol (△9-THC), cannabinol, cannabidiol and cannabichromene were detected in commercially available cannabis seeds by silica gel TLC and gas chromatography. These cannabinoids existed in rather high content (0.10-2.02mg/100g of seeds) in the feed for birds, especially bracts (82.3-441mg/100g). When the suspension prepared from the benzene washing solution of cannabis seeds, BenW, was administered at a dose of 3mg/kg corresponding to △9-THC into a mouse, i.v., BenW caused hypothermia, catalepsy, pentobarbital-induced sleep prolongation and suppression of locomotor activity. These pharmacological activities of BenW were significantly higher than those of △9-THC (3mg/kg, i.v.). These results may indicate the necessity to reconsider the present regulations on marihuana.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 118 (9), 408-414, 1998
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282681130762496
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- NII Article ID
- 110003649170
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 4551447
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed