キノリン系化合物の合成研究 (第8報)

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書誌事項

タイトル別名
  • Studies on the Synthesis of Quinoline Compounds. VIII
  • 4-クロロキナルジン系化合物とサリチルアミドの縮合反応
  • Condensation Reaction of 4-Chloroquinaldine Compounds and Salicylamide

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説明

It was discovered that salicylamide can be used as an amination agent. Condensation of salicylamide with 4-chloroquinaldine compounds results in the formation of compounds of N-(2-methyl-4-quinolyl)salicylamide and 4-aminoquinaldine types, differing from the case of m- and p-hydroxybenzamides, the hydroxyl being stabilized by intramolecular chelation and the acid amide acting like an amine. On the other hand, condensation of m- and p-hydroxybenzamide with 4-chloroquinaldine compounds results in hydroxyl substitution and compound of 4-(carbamoylphenoxy)quinaldine type is formed.

収録刊行物

  • 薬学雑誌

    薬学雑誌 81 (3), 352-358, 1961

    公益社団法人 日本薬学会

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