DKB (3', 4'-Dideoxykanamycin B) の内耳毒性に関する実験的研究

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  • THE TOXIC EFFECT OF DKB (3', 4'-DIDEOXYKANAMYCIN B) ON THE INNER EAR
  • DKB 3 , 4 -Dideoxykanamycin B ノ ナイジ ドクセイ ニ カンスル ジッケンテキ ケンキュウ

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The toxic action of DKB on mice was studied with special regard to the ototoxic action. DKB was found to be more toxic than vistamycin, same toxic as kanamycin, kanendomycin, but less toxic than gentamicin with regard to toxicity/g/body weight.<BR>Toxic reactions were observed in the cochlear and vestibular sensory epithelia with more severe reactions in the cochlear than the vestibular system.<BR>Degeneration appeared first in the outer hair cells in the basal turn of the cochlea starting with the increasing of lysosomes, degeneration of mitochondria in the subcuticle area and resulting in the complete loss of hair cells, but stria vascularis and spiral ligament showed little change.<BR>Severe changes were observed in the sensory epithelium of the cristae ampullares and utricular maculae. Early changes with hair swelling and fusion, degeneration of mitochondria and ballooning of the cell surface were observed leading to complete degeneration first of the type I and later of the type II hair cells.

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