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Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake).

DOI
  • Yamada Yuko
    Laboratory of Microbiology, Koin Women's College of Pharmacy
  • Nanba Hiroaki
    Laboratory of Microbiology, Koin Women's College of Pharmacy
  • Kuroda Hisatora
    Laboratory of Microbiology, Koin Women's College of Pharmacy

Bibliographic Information

Other Title
  • マイタケ子実体抽出物の経口投与による抗腫瘍機作

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Abstract

We conducted a footpad swelling test to clarify whether a delayed type hypersensitivity (DTH) reaction against tumor antigen is potentiated by oral administration of D fraction extracted and purified from fruit body of Grifola frondosa (maitake), with a ratio of β-glucan to protein of 7: 3. When the antigen was injected in D fraction administered tumorbearing mice (D-mice), footpad swelling was observed, suggesting that a DTH reaction against the tumor antigen was potentiated by oral administration of D-fraction. Winn assay was carried out with whole spleen cells from D-mice and Lyt-2-spleen cells in which Lyt-2+ cells corresponding to cytotoxic T cells (CTL) were eliminated by treating with anti-Lyt-2 monoclonal antibody and complement. Even after CTL were eliminated, tumor neutralizing activity was at no time impaired, indicating that spleen cells other than CTL play a leading role in tumor cytotoxicity.<BR>We hypothesize from the above results, that a DTH reaction, manifested by the combined action of delayed hypersensitivity T cells (Tdh) and macrophages (MΦ), was potentiated by oral administration of D-fraction. Even when CTL are absent, there is a high degree of tumor involution. But D-fraction did not activate gut-associated lymphoid tissue (GALT) and Peyer's patch (PP), by oral administration.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 38 (8), 790-796, 1990

    Japanese Society of Chemotherapy

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