マイタケ子実体抽出物の経口投与による抗腫瘍機作
書誌事項
- タイトル別名
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- Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake).
説明
We conducted a footpad swelling test to clarify whether a delayed type hypersensitivity (DTH) reaction against tumor antigen is potentiated by oral administration of D fraction extracted and purified from fruit body of Grifola frondosa (maitake), with a ratio of β-glucan to protein of 7: 3. When the antigen was injected in D fraction administered tumorbearing mice (D-mice), footpad swelling was observed, suggesting that a DTH reaction against the tumor antigen was potentiated by oral administration of D-fraction. Winn assay was carried out with whole spleen cells from D-mice and Lyt-2-spleen cells in which Lyt-2+ cells corresponding to cytotoxic T cells (CTL) were eliminated by treating with anti-Lyt-2 monoclonal antibody and complement. Even after CTL were eliminated, tumor neutralizing activity was at no time impaired, indicating that spleen cells other than CTL play a leading role in tumor cytotoxicity.<BR>We hypothesize from the above results, that a DTH reaction, manifested by the combined action of delayed hypersensitivity T cells (Tdh) and macrophages (MΦ), was potentiated by oral administration of D-fraction. Even when CTL are absent, there is a high degree of tumor involution. But D-fraction did not activate gut-associated lymphoid tissue (GALT) and Peyer's patch (PP), by oral administration.
収録刊行物
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- ＣＨＥＭＯＴＨＥＲＡＰＹ
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ＣＨＥＭＯＴＨＥＲＡＰＹ 38 (8), 790-796, 1990
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681255964416
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- NII論文ID
- 130004197120
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- ISSN
- 18845894
- 00093165
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可