Dihydroxymethyl-furatrizineの抗菌作用と感受性菌の形態変化

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  • BACTERIOLOGICAL AND MORPHOLOGICAL STUDIES ON ANTIBACTERIAL ACTIVITIES OF DIHYDROXYMETHYL-FURATRIZINE
  • Dihydroxymethyl-furatrizine ノ コウキン サヨウ ト カンジュセイキン ノ ケイタイ ヘンカ

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Antibacterial activities of dihydroxymethyl-furatrizine againstEscherichia coli B and Staphylococcus aureus 209 P were investigated and morphological alterations of the drug-treated cells were examined by scanning and transmission electron microscopy. Difference between the action of the drug E.coli and against Staph, aureus was clearly indicated in this experiment : The drug exerts the bactericidal effect on E. coli, but bacteriostatic on Staph. aureus. Further, morphological alterations of the drug-treated cells were also quietly different between both bacteria. After several hours contact with sublethal dose of the drug, the cells of E. coli elongated up to 20-30μ, which was resulted from inhibition of dividing, and partially lysed, while in Staph. aureus, thiny cells with 0.3-0.5μ in diameter were produced by abnormal septation. From these results, the regulatory mechanism of the cell dividing may be possibly affected by this drug.

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