Cefoxitinによる<I>Escherichia coli, Proteus morganii, Serratia marcescens</I>の形態変化について

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  • MORPHOLOGICAL ALTERATIONS IN <I>ESCHERICHIA COLI</I> NO.29, <I>PROTEUS MORGANH</I> NO.101 AND <I>SERRATIA MARCESCENS</I> T-55 EXPOSED TO CEFOXITIN
  • Cefoxitin ニヨル Escherichia coli Proteus

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The effects of cefoxitin (CFX) on the morphology of E. coli No.29, Pr. morganii No.101 and Ser. marcescens T-55 were examined by the phase contrast microscope and the scanning electron microscope. The following results were obtained:<BR>1) CFX induced filament formations and spheroplast-like structures at the minimum inhibitory concentration (MIC) with E. coli No.29.<BR>These morphological alterations of E. coli No.29, treated with CFX, were similar to those with cephalothin (CET) and cefazolin (CEZ), used as control drugs.<BR>2) Spheroplast formations and cell lysis were observed when CFX was allowed to act on Pr. morganii No.101 and Ser. marcescens T-55 (β-lactam antibiotic resistant strain). When treated with CET and CEZ, most cells grew similarly to the untreated controls of Pr. morganii No.101 and Ser. marcescens T-55.

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