複雑性尿路感染症に対するCinoxacinの臨床効果

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書誌事項

タイトル別名
  • CLINICAL EVALUATION OF CINOXACIN IN COMPLICATED URINARY TRACT INFECTIONS
  • フクザツセイ ニョウロ カンセンショウ ニ タイスル Cinoxacin ノ
  • A COMPARATIVE STUDY WITH NALIDIXIC ACID BY A RANDOMIZED DOUBLE BLIND METHOD
  • Nalidixic acidとの二重盲検比較試験
公開日
1980
DOI
  • 10.11250/chemotherapy1953.28.supplement4_377
公開者
公益社団法人 日本化学療法学会

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説明

The clinical efficacy, usefulness and safety of cinoxacin (CINX) in complicated urinary tract infections were evaluated by double blind comparison with nalidixic acid (NA). CINX and NA were administered 400mg b. i. d. and 1, 000mg t. i. d. for 5 days respectively.<BR>The results were summarized as follows;<BR>1. As to the overall clinical efficacy the rates of excellent, moderate and poor were 15%, 23% and 62% with CINX in 113 patients and 17%, 13% and 70% with NA in 111 patients, respectively without significant difference between the two groups.<BR>2. On evaluation of efficacy on bacteriuria, CINX showed significantly higher clearance rate than NA against S. marcescens and bacteria having MIC of over 800μg/ml.<BR>3. In the global judgement made by the attending physicians, CINX showed better tendency in the efficacy and usefulness than that of NA.<BR>4. Because both CINX and NA showed no antibacterial activity against P. aeruginosa, the same evaluations were made in the cases excluded P. aeruginosa. CINX showed significantly higher efficacy rate than NA on overall clinical efficacy in catheter indwelt patients.<BR>5. Incidence of adverse reaction was 2.1% and 6.0% in CINX and NA respectively. Deterioration on clinical findings was observed in one case in each group.<BR>From the above results, CINX would be a useful oral drug in the treatment of complicated urinary tract infections.

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