PHARMACOKINETICS AND CLINICAL EVALUATION OF CINOXACIN IN URINARY TRACT INFECTIONS

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  • 尿路感染症に対するCinoxacinの基礎的, 臨床的検討
  • ニョウロ カンセンショウ ニ タイスル Cinoxacin ノ キソテキ リン

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Abstract

Cinoxacin, a new synthetic antibacterial agent, was evaluated on pharmacokinetics in healthy adults and clinical effect for urinary tract infections.<BR>1) The mean peak serum concentration in 6 healthy male adults, when each subject received a single 400mg oral dose of cinoxacin, was 8.5μg/ml with bioassay. Fifty-two per cent of the drug was excreted in the urine within the first 8 hours.<BR>2) Its clinical effect for 47 cases of acute simple cystitis included 34 excellent effective cases, 12 moderate effective cases and 1 poor effective case, the overall effective rate being 97.9%. The clinical effect for 14 chronic complicated cystitis contained 2 excellent effective cases, 5 moderate effective cases and 7 poor effective cases, the rate of effectiveness being 50%.<BR>3) As for side effects, slight epigastralgia was observed in 2 cases.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 28 (Supplement4), 242-255, 1980

    Japanese Society of Chemotherapy

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