尿路感染症に対するCS-807の臨床的検討

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  • CS-807 IN UROLOGICAL INFECTIONS

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CS-807 is characterized by a broad antibacterial spectrum, covering gram-positive and-negative bacteria, and stability to, β-lactamases.<BR>We used this compound in the treatment of 52 patients with urinary tract infection (UTI) to investigate the drug's efficacy, safety, and usefulness.<BR>CS-807 was administered to 24 patients with acute uncomplicated cystitis, 1 with gonorrheal urethritis and 27 with complicated UTI.<BR>Efficacy was generally evaluated according to the criteria of the Japanese UTI Committee.<BR>In cases of acute uncomplicated cystitis, efficacy was rated as excellent in eight cases and moderate in four, the efficacy rate being 100%.<BR>In cases of chronic complicated UTI, efficacy was excellent in 2, moderate in 6 and poor in 2 cases, the efficacy rate being 80%. All these cases met the Japanese UTI criteria.<BR>Of 52 treated cases, side-effects were noted in two, 1 each of diarrhea and formation of aphthae in the oral cavity. Abnormal clinical laboratory data due to CS-807 were not observed in any of the cases.<BR>In view of the above results, we consider CS-807 to be a useful compound for the treatment of urinary tract infections.

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