新生児および乳児におけるｖａｎｃｏｍｙｃｉｎ体内動態にもとづく投与指針の構築

DOI

書誌事項

タイトル別名
  • Development of a dosage guideline based on vancomycin pharmacokinetics in neonates and infants

抄録

To establish a dosage guideline for vancomycin (VCM) in hospitalized infants and neonates, we studied pharmacokinetic parameters. Subjects were 5 neonates and 16 infants undergoing vancomycin therapy to treat infections by MRSA during between August 1998 and August 2001 at our hospital. Pharmacokinetic parameters of vancomycin were estimated by the Sawchuk-Zaske method. A good correlation was obtained between VCM clearance (CL) and body weight (BW). Although good correlations were obtained between serum creatinine (Scr) and the CL and between Scr and elimination half-life, no good correlations were obtained between Vd and Scr and between Vd and BW. Vd in infants and neonates was significantly less than that in adults (0.499±0.199 versus 0.717±0.0249L/h/kg, P<0.05). These results suggested that BW and Scr are useful parameters for developing a dosage guideline.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282681262258048
  • NII論文ID
    130004298156
  • DOI
    10.11250/chemotherapy1995.51.87
  • ISSN
    18845886
    13407007
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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