Development of a dosage guideline based on vancomycin pharmacokinetics in neonates and infants

DOI
  • Imano Hideki
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Ueno Kazuyuki
    Department of Pharmacy and Department of Pharmacy and Clinical Laboratory Medicine, National Cardiovascular Center
  • Ikura Megumi
    Department of Pharmacy and Department of Pharmacy and Clinical Laboratory Medicine, National Cardiovascular Center
  • Yoshimura Hironori
    Department of Pharmacy and Department of Pharmacy and Clinical Laboratory Medicine, National Cardiovascular Center
  • Mitsutake Kotaro
    National Cardiovascular Center

Bibliographic Information

Other Title
  • 新生児および乳児におけるｖａｎｃｏｍｙｃｉｎ体内動態にもとづく投与指針の構築

Abstract

To establish a dosage guideline for vancomycin (VCM) in hospitalized infants and neonates, we studied pharmacokinetic parameters. Subjects were 5 neonates and 16 infants undergoing vancomycin therapy to treat infections by MRSA during between August 1998 and August 2001 at our hospital. Pharmacokinetic parameters of vancomycin were estimated by the Sawchuk-Zaske method. A good correlation was obtained between VCM clearance (CL) and body weight (BW). Although good correlations were obtained between serum creatinine (Scr) and the CL and between Scr and elimination half-life, no good correlations were obtained between Vd and Scr and between Vd and BW. Vd in infants and neonates was significantly less than that in adults (0.499±0.199 versus 0.717±0.0249L/h/kg, P<0.05). These results suggested that BW and Scr are useful parameters for developing a dosage guideline.

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Keywords

Details 詳細情報について

  • CRID
    1390282681262258048
  • NII Article ID
    130004298156
  • DOI
    10.11250/chemotherapy1995.51.87
  • ISSN
    18845886
    13407007
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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