Ｆｌｏｍｏｘｅｆのすい液移行に関する臨床的検討

DOI

書誌事項

タイトル別名
  • Clinical study of penetration of flomoxef into serum and pancreatic juice.

この論文をさがす

説明

To evaluate the organ penetration of flomoxef (FMOX), we investigated its concentration in serum and pancreatic juice of 14 patients after intravenous injection of a 2 g FMOX. The results obtained were as follows:<BR>1. The peak concentration of FMOX in serum was 134.3±32.1 μg/ml and occured 30 minutes after administration.<BR>2. The peak concentration of FMOX in pancreatic juice was 4.69±4.12 μg/ml and occured 30 minutes after administration.<BR>3. High concentrations of FMOX in pancreatic juice were observed even at 2 hours after administration.<BR>4. Bacteria isorated from drained pancreatic juice were mainly Escherichia coli and Klebsiella pneumoniae for which the MIC of FMOX was less than 0.1 μg/ml. Thus FMOX was affective against these bacteria in pancreatic juice.<BR>5. Rates of penetration of FMOX into pancreata affected by fibrosis were lower than into pan-creata without fibrosis.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282681262522496
  • NII論文ID
    130004297833
  • DOI
    10.11250/chemotherapy1995.45.741
  • ISSN
    18845886
    13407007
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ