Effect of Short- and Medium-chain Fatty Acid Intake on Cognitive Score Decline over 8 Years among Community-dwelling Elderly

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  • Otsuka Rei
    Section of NILS-LSA （National Institute for Longevity Sciences-Longitudinal Study of Aging）, National Center for Geriatrics and Gerontology
  • Kato Yuki
    Section of NILS-LSA （National Institute for Longevity Sciences-Longitudinal Study of Aging）, National Center for Geriatrics and Gerontology
  • Nishita Yukiko
    Section of NILS-LSA （National Institute for Longevity Sciences-Longitudinal Study of Aging）, National Center for Geriatrics and Gerontology
  • Tange Chikako
    Section of NILS-LSA （National Institute for Longevity Sciences-Longitudinal Study of Aging）, National Center for Geriatrics and Gerontology
  • Imai Tomoko
    Section of NILS-LSA （National Institute for Longevity Sciences-Longitudinal Study of Aging）, National Center for Geriatrics and Gerontology Faculty of Human Life and Science, Doshisha Women’s College of Liberal Arts
  • Ando Fujiko
    Section of NILS-LSA （National Institute for Longevity Sciences-Longitudinal Study of Aging）, National Center for Geriatrics and Gerontology Faculty of Health and Medical Sciences, Aichi Shukutoku University
  • Shimokata Hiroshi
    Section of NILS-LSA （National Institute for Longevity Sciences-Longitudinal Study of Aging）, National Center for Geriatrics and Gerontology Graduate School of Nutritional Sciences, Nagoya University of Art and Science

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Other Title
  • 地域在住高齢者における短鎖および中鎖脂肪酸摂取が8年間の認知機能得点低下に及ぼす影響
  • チイキ ザイジュウ コウレイシャ ニ オケル タンサ オヨビ チュウ サ シボウサン セッシュ ガ 8ネンカン ノ ニンチ キノウ トクテン テイカ ニ オヨボス エイキョウ

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Abstract

To clarify any associations of short- and medium-chain fatty acid intake with cognitive decline, we studied 298 men and 272 women aged 60 years and older at the baseline who participated at least once in the follow-up study of the National Institute for Longevity Sciences - Longitudinal Study of Aging. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) . Nutritional intake was assessed using a 3-day dietary record. Cumulative data for participants with an MMSE score of >27 in the second wave (baseline) were analyzed using a generalized estimation equation. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) for an MMSE score of ≤27 (cognitive score decline) in each study wave according to a 1 standard deviation (SD) increase of short-, medium-, and long-chain fatty acid intake at the baseline were estimated after adjusting for sex, age, follow-up time and other covariates. The multivariate-adjusted OR for a decline in MMSE score (≤27) was 0.86 (95％CI: 0.75-0.98) with a 1-SD increase intake of short-chain fatty acids (181 mg/day) , 0.84 (0.74-0.95) for medium-chain fatty acids (232 mg/day) , and 0.89 (0.76-1.04) for long-chain fatty acids. Short- and medium-chain fatty acid intake may prevent cognitive score decline in community-dwelling elderly.

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