Molecular and Nutritional Biochemical Study of Cholesterol Metabolism Regulation (Young Investigator Award of JSNFS (2011))

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  • Inoue Jun
    Department of Applied Biological Chemistry, The University of Tokyo

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  • コレステロール恒常性に関する分子栄養生化学的研究　　（平成２３年度日本栄養・食糧学会奨励賞受賞）
  • コレステロール コウジョウセイ ニ カンスル ブンシ エイヨウ セイカガクテキ ケンキュウ ヘイセイ 23ネンド ニホン エイヨウ ショクリョウ ガッカイ ショウレイショウ ジュショウ
  • Molecular and Nutritional Biochemical Study of Cholesterol Metabolism Regulation
  • (Young Investigator Award of JSNFS (2011))
  • (平成23年度日本栄養・食糧学会奨励賞受賞)

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Abstract

In humans, cholesterol is derived from two main sources: diet and de novo synthesis in the liver. Cholesterol homeostasis is tightly regulated at the transcriptional, translational, and post-translational levels, and its disruption increases the risk of arteriosclerotic disease. Sterol regulatory element-binding proteins (SREBPs) regulate a wide variety of genes involved in cholesterol and fatty acid synthesis, and function as the main regulator of cholesterol homeostasis. In the present study, we analyzed the molecular mechanisms controlling the activities of SREBPs and identified several novel mechanisms. This review focuses on the latest developments in our understanding of SREBP regulation.

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