高タンパク質食を投与した老化促進モデルマウスの赤血球および肝臓の抗酸化性酵素活性ならびに酸化タンパク質レベルの変動

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  • Effect of a High-protein Diet on Activities of Antioxidative Enzymes and Oxidized Protein Levels in Erythrocytes and Liver of Senescence-Accelerated Mice (SAMs).
  • コウ タンパクシツショク オ トウヨシタ ロウカ ソクシン モデル マウス ノ

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A study was designed to assess the effects of a high-protein diet on the activities of several enzymes involved in the cellular antioxidative defence mechanism. Two strains of mice, a senescence-prone series (SAM-P/1) and a senescence-resistant series (SAM-R/1), were each divided into two groups, and fed either a control (20% casein) or a high-protein (40% casein) diet, respectively, for 11 months from the age of 2 months. Blood and liver were assayed for specific activities of catalase, superoxide dismutase (SOD), and glutathione peroxidase, and the levels of oxidized protein. Ingestion of the high-protein diet decreased the specific activity of catalase in the erythrocytes from both strains of mice, and decreased that of SOD in liver from both strains of mice; however the activity of SOD in erythrocytes from SAM-R/1 was increased. In accordance with these changes, ingestion of the high-protein diet produced an increase in the level of oxidized protein, compared with ingestion the control diet, in erythrocytes from SAM-R/1, and a much more significant increase in erythrocytes from SAM-P/1. There was also an increase in the level of oxidized protein in plasma from SAM-P/1. These results are largely, if not completely, consistent with the notion that high-protein ingestion accelerates the cellular aging process by augmenting the level of oxidized protein in erythrocytes.

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