書誌事項
- タイトル別名
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- Modulatory Effect of Coffee on Restrained Stress-induced Release of Neurotransmitters in Rat.
- ラット ニ オケル コウソク ストレス ニ トモナウ シンケイ デンタツ ブッシツ ホウシュツ ニ タイスル コーヒー ノ ヨクセイ サヨウ
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説明
We investigated whether coffee and its components (caffeine and chlorogenic acid) reduce stress in rats. In vivo microdialysis was used to characterize the effects of coffee, stress, and their interaction on the serotonergic and dopaminergic systems. Immobilization of the rats for 100min markedly increased the hippocampal levels of dopamine (DA) and serotonin (5-HT). Thereafter, 100min of rest restored the levels of DA and 5-HT to basal values. Treatment with 33mg/kg instant coffee (equivalent to the amount contained in one cup of coffee) or 1.7mg/kg caffeine (equivalent to one cup of coffee) reduced the second restraint-induced increase of the neurotransmitters, especially 5-HT. On the other hand, neither saline nor 1.7mg/kg chlorogenic acid (equivalent to one cup of coffee) reduced the increases. These results suggest that coffee administration helps to relax rats subjected to restraint-induced stress, and that this effect could be due to caffeine. Taken together, these findings suggest that coffee has a modulating effect on the stress response in rats.
収録刊行物
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- 日本栄養・食糧学会誌
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日本栄養・食糧学会誌 55 (2), 85-91, 2002
公益社団法人 日本栄養・食糧学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282681270411008
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- NII論文ID
- 10008561282
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- NII書誌ID
- AN00311992
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- ISSN
- 18832849
- 02873516
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- NDL書誌ID
- 6148754
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
