書誌事項
- タイトル別名
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- Hypotriglyceridemic Effect of Globin Digest on Subjects with Borderline Hyperlipidemia.
- キョウカイイキ コウシ ケツショウ ヒケンシャ ニ オケル グロビンタンパク ブンカイブツ ノ ケッセイ トリグリセリド テイカ サヨウ
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It has already been reported that globin digest (GD) exerts a hypotriglyceridemic action in laboratory animals and humans. A tetrapeptide, Val-Val-Tyr-Pro, extracted from GD, has also been shown to be 7000-times more active than the parent GD. We studied the hypotriglyceridemic effect of GD in subjects with borderline hyperlipidemia. In normal subjects, 1g of GD showed sufficient hypotriglyceridemic action. When borderline hypertriglyceridemic subjects were administered 1g of GD as a beverage with 40g of fat, the increases in serum and chylomicron (CM) TGs at 1-5h after the administration were suppressed to 25-50% of the control values (without GD). The areas under the serum TG and CM-TG concentration curves (AUCs; 0-6h) were significantly decreased to about 40% of the control, respectively. GD enhanced the elimination rate constants of TG and CM-TG in borderline hypertriglyceridemic subjects, and showed a more effective hypotriglyceridemic action than in normal subjects. GD thus appears to be useful for prevention of cardiovascular disease and atherosclerosis in subjects with borderline hypertriglyceridemia.
収録刊行物
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- 日本栄養・食糧学会誌
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日本栄養・食糧学会誌 52 (2), 71-77, 1999
公益社団法人 日本栄養・食糧学会
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詳細情報 詳細情報について
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- CRID
- 1390282681270780288
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- NII論文ID
- 10009713157
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- NII書誌ID
- AN00311992
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- ISSN
- 18832849
- 02873516
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- NDL書誌ID
- 4718243
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可