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POSSIBLE DIFFERENTIAL DIAGNOSIS OF NEUROBLASTOMA FROM RHABDOMYOSARCOMA AND EWING'S SARCOMA BY USING A PANEL OF MONOCLONAL ANTIBODIES
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- SUGIMOTO Tohru
- Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
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- SAWADA Tadashi
- Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
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- ARAKAWA Shoji
- Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
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- MATSUMURA Takafumi
- Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
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- SAKAMOTO Izumi
- Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
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- TAKEUCHI Yoshihiro
- Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
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- REYNOLDS C. Patrick
- U.S. Navy Tissue Bank, Naval Medical Research Institute
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- KEMSHEAD John T.
- Oncology Laboratory, Institute of Child Health
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- HELSON Lawrence
- Memorial Sloan-Kettering Cancer Center
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Description
The accurate diagnosis of malignant tumor type is essential to enable the correct therapeutic regimen to be followed and to predict a patient's prognosis. However, the differential diagnosis of “small-round-cell” tumors, represented by neuroblastoma, rhabdomyosarcoma, lymphoma/leukemia and Ewing's sarcoma, can occasionally be difficult by conventional morphological and biochemical methods. If tumor membrane markers were available, these could provide rapid and accurate diagnostic aids. In the present work, a panel of 9 monoclonal antibodies raised against hematopoietic cells (BA-1, BA-2, J-5 and B7/21), brain cells (UJ-13A, UJ-127-11 and anti-Thy-1), and neuroblastoma cells (HSAN1.2 and PI153/3) was used to analyze the membrane phenotypes of 12 neuroblastoma, 4 rhabdomyosarcoma and 3 Ewing's sarcoma cell lines and cells of 3 fresh bone marrow tumors. BA-1, UJ-127-11 and PI153/3 antibodies may be useful for the differential diagnosis of neuroblastoma from rhabdomyosarcoma and Ewing's sarcoma.
Journal
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- Japanese Journal of Cancer Research GANN
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Japanese Journal of Cancer Research GANN 76 (4), 301-307, 1985
The Japanese Cancer Association
