Further Studies on the Effect of 5‐Iododeoxyuridine on Polyoma Virus Multiplication in Mouse Cells
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- KIMURA Genki
- Deparment of Bacteriology, School of Medicine
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- MORI Ryoichi
- Deparment of Bacteriology, School of Medicine
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- AMAKO Kazunobu
- Deparment of Bacteriology, School of Medicine
書誌事項
- タイトル別名
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- Further Studies on the Effect of 5-Iododeoxyuridine on Polyoma Virus Multiplication in Mouse Cells
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抄録
5-Iododeoxyuridine (IUDR) inhibited production of infectious polyoma virus in mouse embryo cells and mouse kidney cells in culture. Deoxythymidine reversed its effect. IUDR did not inactivate infectivity of free virus particles. IUDR did not prevent adsorption and penetration of polyoma virus to cells. The events sensitive to IUDR treatment occurred at around 20 hours after infection. The cytopathic effects of polyoma virus, including emergence of DNA containing-inclusions in the nucleus, were observable in infected cells in which viral replication was completely arrested by IUDR. It was shown by fluorescent antibody technique in infected mouse embryo cells and by complement fixation test in infected mouse kidney cells that IUDR inhibited completely the synthesis of viral antigen. No virus-like particles were demonstrated in the IUDR-treated infected-mouse kidney cells by electron microscope examinations.
収録刊行物
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- Japanese Journal of Microbiology
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Japanese Journal of Microbiology 10 (4), 211-219, 1966
財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390282681295814784
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- NII論文ID
- 130004085107
- 40018694406
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- NII書誌ID
- AA00246855
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- COI
- 1:CAS:528:DyaF2sXktlSqsb0%3D
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- NDL書誌ID
- 8511486
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- ISSN
- 00215139
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可