Antiinfluenzal Effect of Rugulosin

NAKAMURA Shinichi, NII Fusako, INOUE Satoru, NAKANISHI Isao, SHIMIZU Masanao

doi:10.1111/j.1348-0421.1974.tb00736.x

Antiinfluenzal Effect of Rugulosin

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NAKAMURA Shinichi

Research and Development Division, Dainippon Pharmaceutical Co., Ltd
NII Fusako

Research and Development Division, Dainippon Pharmaceutical Co., Ltd
INOUE Satoru

Research and Development Division, Dainippon Pharmaceutical Co., Ltd
NAKANISHI Isao

Research and Development Division, Dainippon Pharmaceutical Co., Ltd
SHIMIZU Masanao

Research and Development Division, Dainippon Pharmaceutical Co., Ltd

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抄録

(-)Rugulosin showed an antiinfluenzal effect in the allantoic cavity of chicken eggs as well as in cultured chorioallantois, proving itself to be more potent than 1-adamantanamine. Also, (-)rugulo-sin, when administered by inhalation, was as effective for protection of mice against aerosol influenzal infection as orally administered 1-adamantanamine. The effect of (-)rugulosin seemed to be mainly due to direct inactivation of influenza virus.