Effect of exogenous polyunsaturated fatty acids on lipogenic enzyme activity in rat liver under fixed carbohydrate consumption.
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- 武藤 泰敏
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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- 篠原 直美
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo Indiana University School fo Medicine
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- バンホトカセム セームシ
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo Department of Pediatrics, Ramathibodi Hospital
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- 飯豊 紀子
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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- 細谷 憲政
- Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
書誌事項
- タイトル別名
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- Effect of exogenous polyunsaturated fat
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説明
Studies were conducted to evaluate specific dampening of hyperlipo-genesis (i.e. enhanced lipogenic enzyme activity of the liver in rats refed a high carbohydrate, fat-free diet: F-diet) by exogenous polyunsaturated fatty acids under fixed carbohydrate consumption.<br> In force-feeding of rats with a linoleate-rich diet (F-diet containing 4.5 safflower oil), the lipogenic enzyme activities; fatty acid synthetase (FAS) and malic enzyme (ME), in the liver supernatantt were found to be significantly lower than those in rats force-fed only an F-diet (p<0.02), under conditions of identical consumption of carbohydrate. Among the various methylesters of unsaturated fatty acids administered by gastric intubation at a dose of 0.3g per 100g body weight, arachidonate was most potent in bringing about a significant reduction of hyper-lipogenesis without seriously affecting food intakes.<br> During the same three-day experimental period, fatty acid GLC spectra in both the liver and plasma lipids reflected the exogenous input of PUFA. Plasma total fatty acid concentration (mainly triglyceride) significantly de-creased in the arachidonate group (p<0.01).
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 21 (1), 39-47, 1975
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390282681302907648
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- NII論文ID
- 130001372759
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DyaE2MXltFaksLY%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 1585104
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- PubMed
- 1151500
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可