Inhibition of β-Sitosterol on Intestinal Cholesterol Absorption in Rat Using In Vivo Dual Isotope Ratio Method

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  • 四童子 好広
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • 渡部 誠
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • 奥 恒行
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
  • 武藤 泰敏
    Department of Medicine, GU u University, School of Medicine
  • 細谷 憲政
    Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo

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タイトル別名
  • Inhibition of .BETA.-sitosterol on intestinal cholesterol absorption in rat using in vivo dual isotope ratio method.
  • Inhibition of ベータ Sitosterol on Intesti
  • Inhibition of β-sitosterol in intestinal cholesterol absorption in rat using in vivo dual isotope ratio method

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説明

The inhibitory effects of β-sitosterol on intestinal cholesterol absorption were studied by means of a dual isotope plasma ratio method (in vivo), which is a new technique for the measurement of cholesterol absorption, as well as a ligated-loop method (in situ). The results obtained were as follows:<br> 1. The absorption of β-sitosterol itself was significantly less than cholesterol. Cholesterol was selectively absorbed from rat intestine.<br> 2. When 100 to 1, 000μg of β-sitosterol were added to the dose solution containing 10μg of cholesterol, cholesterol absorption by the in vivo experiment decreased with the increase of additional β-sitosterol.<br> 3. A similar inhibitory effect of β-sitosterol was observed by the in situ ligated-loop method.<br> These results suggest that β-sitosterol actually inhibits cholesterol absorption in the physiological state of an animal.

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