Sex-Reversed Somatic Cell Cloning in the Mouse

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  • INOUE Kimiko
    BioResource Center, RIKEN Graduate School of Life and Environmental Sciences, University of Tsukuba
  • OGONUKI Narumi
    BioResource Center, RIKEN
  • MEKADA Kazuyuki
    BioResource Center, RIKEN
  • YOSHIKI Atsushi
    BioResource Center, RIKEN
  • SADO Takashi
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University
  • OGURA Atsuo
    BioResource Center, RIKEN Graduate School of Life and Environmental Sciences, University of Tsukuba The Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo

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Somatic cell nuclear transfer has many potential applications in the fields of basic and applied sciences. However, it has a disadvantage that can never be overcome technically-the inflexibility of the sex of the offspring. Here, we report an accidental birth of a female mouse following nuclear transfer using an immature Sertoli cell. We produced a batch of 27 clones in a nuclear transfer experiment using Sertoli cells collected from neonatal male mice. Among them, one pup was female. This "male-derived female" clone grew into a normal adult and produced offspring by natural mating with a littermate. Chromosomal analysis revealed that the female clone had a 39,X karyotype, indicating that the Y chromosome had been deleted in the donor cell or at some early step during nuclear transfer. This finding suggests the possibility of resuming sexual reproduction after a single male is cloned, which should be especially useful for reviving extinct or endangered species.<br>

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