大気中微小粒子状物質（PM2.5）から生じる酸化ストレスと脳神経障害：第2部

DOI Web Site Web Site PubMed 被引用文献1件 参考文献44件 オープンアクセス

書誌事項

タイトル別名
  • Oxidative Stress Derived from Airborne Fine and Ultrafine Particles and the Effects on Brain-Nervous System: Part 2
  • タイキ チュウ ビショウリュウシジョウ ブッシツ(PM2.5)カラ ショウジル サンカ ストレス ト ノウ シンケイ ショウガイ(ダイ2ブ)
公開日
2015
資源種別
journal article
DOI
  • 10.1265/jjh.70.220
公開者
一般社団法人日本衛生学会

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説明

Traffic-related air pollution is a major contributor to urban air pollution. Diesel exhaust (DE) is its most important component of near-road and urban air pollutions and is commonly used as a surrogate model of air pollution in health effects studies. In particular, diesel exhaust particles (DEPs) and nanoparticles in DEPs are the components considered hazardous for health. It is widely known that exposure to DEPs is associated with mortality caused by respiratory and cardiovascular diseases. Recently, evidence has been accumulating showing that DEPs and nanoparticles may cause neurodegenerative disorders. Here, we introduce evidence suggesting their association with these disorders. The chemical components and the translocation of DEPs and nanoparticles to the brain are described in part 1. In part 2, we introduce the mechanism of development of neurodegenerative diseases such as stroke, Alzheimer’s disease, and Parkinson’s disease via oxidative stress and inflammatory events. Furthermore, there are many lines of epidemiological evidence showing that the particulates impair cognitive function and ability of memory through oxidative and inflammatory events in the brain. These lines of evidences are supported by many animal experiments on neurological disorders.

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