ラット胃粘膜Ｐｒｏｓｔａｇｌａｎｄｉｎｓに関する研究　ＩＸ　　センナによる影響

DOI PubMed

書誌事項

タイトル別名
  • PROSTAGLANDINS IN RAT GASTRIC MUCOSA (9TH REPORT)
  • センナによる影響

この論文をさがす

説明

We investigated the effect of senna, one of the laxatives, on the levels of prostaglandins (PG) in the rat gastric mucosa. Intragastric (i.g.) instillation of senna (3mg/kg) increased PGE2 by 3.6 times (p<0.025), PGI2 by 3.7 times (p<0.01), TXA2 by 2.8 times (p<0.01), in the fundic mucosa; PGE2 by 2.9 times (p<0.01), PGI2 by 3.4 times (P<0.025), TXA2 by 1.5 times (N.S.) in the antral mucosa.<br>High dose of senna (300mg/kg, i.g.) also increased PG levels dose-independently. I.g. instillation of senna (300mg/kg) inhibited the gastric lesions induced by the necrotizing agent (0.6N HCl)-the ulcer index, 10.0±8.3; significantly different at p<0.05 from controls indicating the ulcer index at 49.2± 12.1-. These results suggest that the cytoprotective effect of senna is mediated by the endogenous PG in the gastric mucosa.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282681374316544
  • NII論文ID
    130001063783
  • DOI
    10.11405/nisshoshi1964.81.825
  • COI
    1:CAS:528:DyaL2cXkvVekurk%3D
  • ISSN
    13497693
    04466586
  • PubMed
    6379227
  • 本文言語コード
    ja
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ