Effects of .BETA.-cryptoxanthin-fortified Satsuma Mandarin (Citrus unshiu Marc.) Juice on Liver Function and the Serum Lipid Profile

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  • Ohshima Makoto
    Nihon Kajitsukogyo Co., Ltd.
  • Sugiura Minoru
    Research Team for Health Benefits of Fruits, National Institute of Fruit Tree Science
  • Ueda Kayo
    Department of Hygiene, Environmental, Humanity and Health System Science, Yamaguchi University School of Medicine

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Other Title
  • β‐クリプトキサンチン高含有ウンシュウミカン果汁の摂取が肝機能および脂質代謝に及ぼす影響
  • β-クリプトキサンチン高含有ウンシュウミカン果汁の摂取が肝機能および脂質代謝に及ぼす影響
  • ベータ クリプトキサンチン コウガンユウ ウンシュウミカン カジュウ ノ セッシュ ガ カン キノウ オヨビ シシツ タイシャ ニ オヨボス エイキョウ

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β-Cryptoxanthin (β-CRY) is a carotenoid pigment especially found in satsuma mandarins (Citrus unshiu Marc.). Recent epidemiologic studies have reported inverse associations of serum β-CRY with the risk for cancer, diabetes and liver dysfunction. This double-blinded, placebo-controlled study examined the effect of β-CRY-fortified mandarin juice on liver function and the serum lipid profile. At total of 26 obese male subjects with mild dyslipidemia received mandarin juice fortified without (n=13) or with β-CRY (n=13) once a day for up to 8 weeks. After the intake of mandarin juice for 4 and 8 weeks, a significant increase in serum β-CRY was observed in both groups ; the level was notable for the β-CRY-fortified juice group. Serum alanine aminotransferase and γ-glutamyltransferase levels in the β-CRY-fortified juice group were significantly lower at 8 weeks than those at 4 weeks. Cross-sectional analysis showed significant inverse correlations between serum liver enzyme and serum β-CRY concentrations at 4 and 8 weeks ; there were no correlations at baseline. These inverse correlations were more evident at 8 weeks. Moreover, serum HDLand LDL-cholesterol levels in the β-CRY-fortified juice group were decreased after 8 weeks, but were not significant different from the non-fortified juice group. These results suggest that intake of β-CRY-rich mandarin juice may be effective for improving liver function.

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