The study on the prophylactic effects of agricultural products on lifestyle related diseases Part I. Adipocyte Functions and the Insulin Sensitivity of Extracts from 5 Fruits Including Peach, Apple, Plum, Grape(Kyoho) and Apricot.

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  • 農産物の生活習慣病予防作用に関する研究　（第１報）　　モモ，リンゴ，プラム，ブドウ（巨峰），アンズ抽出物による糖・脂質代謝の活性化とインスリン感受性の上昇
  • モモ リンゴ プラム ブドウ キョホウ アンズ チュウシュツブツ ニ ヨル トウ シシツ タイシャ ノ カッセイカ ト インスリン カンジュセイ ノ ジョウショウ
  • The study on the prophylactic effects of agricultural products on lifestyle related diseases Part I
  • 農産物の生活習慣病予防作用に関する研究(第1報)

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Abstract

We studied potential prophylactic effects on diabetes by measuring adipocyte functions and the insulin sensitivity of 5 fruits including peach, apple, plum, grape (Kyoho) and apricot. The following results were obtained: (1) The highly hydrophobic fraction (soluble in ether) in either of the fruits increased the levels of glycerol-3-phosphate dehydrogenase (GPDH) and intracellular lipid droplet, indicating activation of adipocyte functions. The activation was dose-dependent in any fruit. In peach, in particular, marked activation was noted at a low concentration, and its less hydrophobic (insoluble in ether) fraction also had a slight activating effect. (2) The highly hydrophobic fractions increased intracellular glucose availability in the presence of insulin, indicating an increase in insulin sensitivity of cells. The increase was the most remarkable in peach, and its less hydrophobic fraction also slightly increased the glucose uptake. The components in the 5 fruits tested in this study, especially in peach, and raise the insulin sensitivity in vitro. These results suggesting prophylactic effects on life-style related diseases such as diabetes.

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