Quantitative Changes in Serum Concentration of Bovine Gut Chitinase in Theileria Infection

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  • FUJIMOTO Wakako
    Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University
  • KIMURA Kazuhiro
    Laboratory of Biochemistry, Graduate School of Veterinary Medicine, Hokkaido University
  • SUZUKI Masako
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • SYUTO Bunei
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • ONUMA Misao
    Laboratory of Infectious Disease, Graduate School of Veterinary Medicine, Hokkaido University
  • IWANAGA Toshihiko
    Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University

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Abstract

Bovine gut chitinase is exclusively produced in the liver and secreted into the blood. In the present study, we established a semi-quantitative method by Western blot analysis for measurement of the chitinase content in blood and examined its alteration during postnatal development and experimental infection with hemoprotozoan parasite in cattle. Its serum levels from 1 week to 1 year of age showed a significant increase only in 3-4-month-old group. The plasma concentration of the gut chitinase was not changed during acute inflammation caused by lipopolysaccharide but increased gradually after a Theileria injection and peaked at 52 days post-infection. It appears that the increase in the blood chitinase levels might be a defensive response in cattle against protozoan infection.<br>

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