Thyroid Hormone Augments GLUT4 Expression and Insulin-Sensitive Glucose Transport System in Differentiating Rat Brown Adipocytes in Culture.
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- SHIMIZU Yasutake
- Department of Medical Biochemistry, Ehime University School of Medicine
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- SHIMAZU Takashi
- Department of Medical Biochemistry, Ehime University School of Medicine
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説明
The effects of triiodothyronine (T3) on differentiation-dependent expression of GLUT and responses of glucose transport to insulin and norepinephrine (NE) were investigated. Precursor cells of brown adipocytes isolated from the interscapular brown adipose tissue of newborn rats were cultured in the absence or presence of various concentrations of T3. Western bolt analysis revealed that treatment with T3 resulted in an increased expression of GLUT4, in a dose-dependent manner, whereas GLUT1 contents were unchanged. In parallel with the increase in GLUT4 expression, T3 improved insulin sensitivity for glucose transport, being accompanied by an increase in maximal transport rate and a reduction of ED50. In contrast, T3-treatment of the brown adipocytes during the differentiation process had little effect on NE-regulatable glucose transport system. These results suggest that T3 plays a predominant role in the development of insulin-sensitive glucose transport during differentiation of brown adipocytes.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 64 (8), 677-681, 2002
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681402706432
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- NII論文ID
- 130000449242
- 110003920897
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD38XnsFOiu74%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 6275412
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- PubMed
- 12237511
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可