Inhibition of Binding of Vibrio vulnificus Hemolysin (VVH) by MβCD
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- SUGIYAMA Hiroyuki
- Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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- KASHIMOTO Takashige
- Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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- UENO Shunji
- Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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- SUSA Nobuyuki
- Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
書誌事項
- タイトル別名
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- Inhibition of Binding of <i>Vibrio vulnificu</i>s Hemolysin (VVH) by MβCD
この論文をさがす
抄録
Vibrio vulnificus secrets a pore-forming toxin called Vibrio vulnificus hemolysin (VVH). In this study, we showed that methyl-beta-cyclodextrin (MβCD), an oligosaccharide, decreased binding of VVH to Chinese hamster ovary (CHO) cells, resulting in inhibition of its cytotoxicity. When the VVH was incubated with MβCD, cytotoxicity of the toxin was inhibited from 100.3 ± 7.2% to 19.6 ± 5.3%. Binding analysis showed that the amount of VVH on the cells was decreased from 101.4 ± 9.2% to 18.1 ± 8.0% only when MβCD was present in the culture media. Our results indicate that the inhibition of cytotoxicity of VVH by MβCD was due to a decrease in the amount of toxin binding to CHO cells.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 75 (5), 649-652, 2013
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681404531584
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- NII論文ID
- 130002502171
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- NII書誌ID
- AA10796138
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- COI
- 1:STN:280:DC%2BC3s3hvValtQ%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 024676529
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- PubMed
- 23238452
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可