Internal medicine: Therapeutic changes of plasma N-terminal pro-brain natriuretic peptide concentrations in 9 dogs with patent ductus arteriosus
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- ARAMAKI Yoshitaka
- Chimura Veterinary Hospital Bay Veterinary Hospital
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- CHIMURA Syuuichi
- Chimura Veterinary Hospital
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- HORI Yasutomo
- Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
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- EGUCHI Tokuhiro
- Chimura Veterinary Hospital
書誌事項
- タイトル別名
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- Therapeutic Changes of Plasma N-Terminal Pro-Brain Natriuretic Peptide Concentrations in 9 Dogs with Patent Ductus Arteriosus
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The plasma N-terminal proBNP (NT-proBNP) concentration is measured for determining the diagnosis and severity of heart failure in dogs. However, it is still unclear whether measurements of circulating NT-proBNP levels provide clinical utility as an indicator of therapeutic efficacy. Thus, we investigated the surgical correction-related changes of plasma NT-proBNP concentrations in 9 dogs with patent ductus arteriosus (PDA). Physical examination, thoracic radiography and echocardiography were conducted both before and after surgery. Similarly, the plasma NT-proBNP concentrations were determined using an enzyme immunoassay for canine pro-BNP. The International Small Animal Cardiac Health Council (ISACHC) class and murmur grade were significantly improved after surgery compared with before surgery. Vertebral heart size (VHS) and cardiothoracic ratio (CTR) were significantly decreased after surgery. Fractional shortening was significantly decreased and relative wall thickness (RWT) was significantly increased after surgery. Furthermore, the plasma NT-proBNP concentrations were significantly decreased by surgical correction. The plasma NT-proBNP concentration showed significant positive correlation with the ISACHC class, murmur grade, VHS and CTR and significant negative correlation with the RWT. Therefore, measurement of plasma NT-proBNP levels can be used to monitor the effectiveness of therapies such as surgical correction of PDA.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 73 (1), 83-88, 2011
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681407799936
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- NII論文ID
- 40018701687
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BC3MXivVahtrY%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 10985394
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- PubMed
- 20823663
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可