Human Atrial Natriuretic Peptide Infusion for a Neonate With Congestive Heart Failure After Total Correction of Total Anomalous Pulmonary Venous Connection
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- Hamawaki Masayoshi
- Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
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- Tomino Tetsuo
- Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
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- Sato Harumitsu
- Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
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- Imura Masato
- Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
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- Suzuki Takeo
- Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
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- Hibino Narutoshi
- The Department of Pediatric Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women’s Medical University, Tokyo, Japan
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説明
A successful case of human atrial natriuretic peptide (HANP) infusion therapy for a neonate who developed congestive heart failure (CHF) after total repair of total anomalous pulmonary venous connection was performed on the first day of life. Following 14h of HANP infusion at incremental doses of 0.125-0.25μg·kg-1·min-1, urine output and hemodynamics dramatically improved. Urine output increased from 1.1 to 10.6ml/h (p<0.0001) and good urinary output (13.0ml/h) was maintained even after discontinuation of the infusion. During the infusion, the heart rate decreased from 166 to 152 beats/min (p<0.0001), and the systemic systolic blood pressure increased from 82 to 103 mmHg (p<0.0001). Central venous pressure was not significantly affected by HANP infusion. This is the first successful case of HANP infusion therapy as the first treatment of post-operative pulmonary hypertension in this age group. This therapy can be used safely and may be useful in neonates with CHF resulting from other causes, but more investigation is needed.
収録刊行物
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- JAPANESE CIRCULATION JOURNAL
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JAPANESE CIRCULATION JOURNAL 64 (9), 708-710, 2000
一般社団法人 日本循環器学会
