殺虫剤サリチオン(2-methoxy-4H-1, 3, 2-benzodioxaphosphorin-2-sulfide)の代謝と毒性

DOI 日本農学文献記事索引 Web Site
  • 大川 秀郎
    九州大学農学部農芸化学教室 Division of Entomology, University of California
  • 江藤 守総
    九州大学農学部農芸化学教室
  • 大島 康義
    九州大学農学部農芸化学教室 明治大学農学部

書誌事項

タイトル別名
  • Metabolism and Toxicity of Salithion, 2-Methoxy-4H-1, 3, 2-Benzodioxaphosphorin-2-Sulfide
  • サッチュウザイ サリチオン 2-methoxy-4H-1 , 3 , 2-benzodioxaphosphorin-2-sulfide ノ タイシャ ト ドクセイ

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説明

Salithion, an insecticide analogous to TOCP-metabolite, did not cause ataxia in chickens injected with a total of 80mg/kg in daily doses. Salithion-32P was synthesized and administered orally to mice and topically to houseflies. Autoradiography of body slices and radioassay of whole body and excreta indicated that Salithion was rapidly decomposed in mice and excreted. Chloroform-soluble 32P in the body was only 2.4% of the administered 32P at three hours after treatment. On the other hand, Salithion persisted in the houseflies for a relatively long time. More than 4% of the applied or 10% of the absorved Salithion was found in the chloroform-soluble fraction of houseflies at 24 hours after treatment. Besides Salithion, only its oxo analog was detected in the chloroform-soluble fraction by the autoradiogram of thin layer chromatography.

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