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Synthesis and Activity of Pyrimidinylpropenamide Antibiotics: The Alkyl Analogues of Sparsomycin
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- NAKAJIMA Noriyuki
- <i>Biotechnology Research Center, Toyama Prefectural University</i>
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- ENOMOTO Takeshi
- <i>Biotechnology Research Center, Toyama Prefectural University</i>
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- WATANABE Takehiro
- <i>Biotechnology Research Center, Toyama Prefectural University</i>
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- MATSUURA Nobuyasu
- <i>Biotechnology Research Center, Toyama Prefectural University</i>
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- UBUKATA Makoto
- <i>Biotechnology Research Center, Toyama Prefectural University</i>
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Description
Facile syntheses of sparsomycin (3) and its four analogues (4-7) based on diastereoselective oxidation of sulfide, sulfenylation, and coupling of 6-methyluracylacryllic acid with monooxodithioacetal amine, are described. Studies on the biological activity of morphological reversion on srcts-NRK cells were also carried out.<br>
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 67 (12), 2556-2566, 2003
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390282681449875712
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- NII Article ID
- 110002694020
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 6795094
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- PubMed
- 14730133
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed