Effects of Polysaccharides from Rhizomes of Curcuma zedoaria on Macrophage Functions.
-
- KIM Kyung Im
- Graduate School of Biotechnology, Korea University
-
- SHIN Kwang Soon
- Department of Food Science and Biotechnology, Kyonggi University
-
- JUN Woo Jin
- Graduate School of Biotechnology, Korea University
-
- HONG Bum Shik
- Graduate School of Biotechnology, Korea University
-
- SHIN Dong Hoon
- Graduate School of Biotechnology, Korea University
-
- CHO Hong Yon
- Graduate School of Biotechnology, Korea University
-
- CHANG Hyo Il
- Graduate School of Biotechnology, Korea University
-
- YOO Seong Mo
- Department of Informational Statistics, Korea University
-
- YANG Han Chul
- Graduate School of Biotechnology, Korea University
この論文をさがす
抄録
The effects of Curcuma zedoaria, which is used as a condiment, in perfumery, and as a medicine, on immune response were investigated by measuring macrophage-stimulating activity in macrophages and RAW 264.7 cells. In this study, CZ-1 and CZ-1-III, the fractions partially purified from C. zedoaria, had a strong, dose-dependent lysosomal enzyme activity. It was suggested that active portions of CZ-1-III were polysaccharides rather than proteins. Phagocytic activity increased as a similar pattern in both the Gram-negative and Gram-positive bacteria, time-dependently. It was demonstrated that CZ-1-III can augment the oxygen burst response but had an even higher activity in vivo than in vitro. Also a significant increase of H2O2, NO, and TNF-α production was observed. However, the production of TNF-α at the concentration of 1,000 μg/ml decreased. These data suggested that C. zedoaria had macrophage-stimulating activity and the possibility of being used as a biological response modifier.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 65 (11), 2369-2377, 2001
公益社団法人 日本農芸化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681450582400
-
- NII論文ID
- 110002693295
-
- NII書誌ID
- AA10824164
-
- COI
- 1:CAS:528:DC%2BD3MXovFOgs70%3D
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 6003798
-
- PubMed
- 11791707
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可