Apolipoprotein A-I of Hyperlipidemia Atherosclerosis Prone (LAP) Quail: cDNA Sequence and Tissue Expression.
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- IWASAKI Hironori
- Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
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- OKU Hirosuke
- Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
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- TODA Takayoshi
- Department of Clinical Laboratory Medicine, School of Medicine, University of The Ryukyus
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- NASU Tetsuo
- Department of Veterinary Anatomy, Faculty of Agriculture, Miyazaki University
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- ODA Koji
- Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
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- MIYAGI Tsuyoshi
- Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
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- CHINEN Isao
- Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
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説明
Apolipoprotein A-I (apo A-I) has an important role in the transport of cholesterol. This study describes the complete nucleotide and deduced amino acid sequence for apo A-I of LAP quail. A full length apo A-I cDNA clone for hyperlipidemia atherosclerosis prone (LAP) quail was isolated from a λgt10 liver cDNA library. The DNA sequence of LAP apo A-I cDNA was similar to that of normal Japanese quail. The deduced amino acid sequence of LAP apo A-I was hence identical to that of normal Japanese quail. LAP apo A-I mRNA is about 1.4 kilobases in length and expressed in a variety of tissues including small intestine, liver, lung, breast muscle, testis, and heart. Although the tissue distribution of apo A-I was similar between strains, LAP quail expressed more apo A-I mRNA than normal Japanese quail in all tissues examined. This tendency was pronounced with the small intestine. Although the concentration of serum apo A-I did not correlate with the tissue expression of mRNA, the observation may suggest that the increased apo A-I expression in LAP strain had some relevance to the susceptibility of this strain to the experimental atherosclerosis.<br>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 63 (1), 29-34, 1999
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681451295488
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- NII論文ID
- 110002679337
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DyaK1MXhtVCktrw%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 4652831
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- PubMed
- 10052118
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可