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Effects of xapA and guaA Disruption on Inosine Accumulation in Escherichia coli
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- SHIMAOKA Megumi
- Fermentation and Biotechnology Laboratories, Ajinomoto Co., Inc.
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- TAKENAKA Yasuhiro
- Fermentation and Biotechnology Laboratories, Ajinomoto Co., Inc.
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- MIHARA Yoko
- Fermentation and Biotechnology Laboratories, Ajinomoto Co., Inc.
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- KURAHASHI Osamu
- Fermentation and Biotechnology Laboratories, Ajinomoto Co., Inc.
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- KAWASAKI Hisashi
- Fermentation and Biotechnology Laboratories, Ajinomoto Co., Inc.
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- MATSUI Hiroshi
- Fermentation and Biotechnology Laboratories, Ajinomoto Co., Inc.
Bibliographic Information
- Other Title
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- Effects of<i>xapA</i>and<i>guaA</i>Disruption on Inosine Accumulation in<i>Escherichia coli</i>
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Description
A xapA-disrupted mutant was studied to minimize hypoxanthine production and to improve inosine productivity in mutants of Escherichia coli. The xapA-disrupted mutant accumulated 5.6 g/l of inosine from 40 g/l of glucose, while the parent strain accumulated 4.6 g/l. This result indicates that xapA is activated in xapA-positive inosine-producers and that xapA disruption might be useful for improving inosine productivity.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (12), 3069-3072, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390282681453826304
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- NII Article ID
- 10018524313
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 8596991
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
