Serum Cholesterol Reduction by Feeding a High-Cholesterol Diet Containing a Lower-Molecular-Weight Polyphenol Fraction from Peanut Skin

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  • TAMURA Tomoko
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • INOUE Naoko
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • SHIMIZU-IBUKA Akiko
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • TADAISHI Miki
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • TAKITA Toshichika
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • ARAI Soichi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • MURA Kiyoshi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

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Feeding a high-cholesterol diet with a water-soluble peanut skin polyphenol fraction to rats reduced their plasma cholesterol level, with an increase in fecal cholesterol excretion. The hypocholesterolemic effect was greater with the lower-molecular-weight rather than higher-molecular-weight polyphenol fraction. This effect was possibly due to some oligomeric polyphenols which reduced the solubility of dietary cholesterol in intestinal bile acid-emulsified micelles.

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