Award reviews: Multiple functions of the S-phase checkpoint mediator

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  • TANAKA Katsunori
    Department of Bioscience, School of Science and Technology, Kwansei Gakuin University Research Center for Environmental Bioscience, School of Science and Technology, Kwansei Gakuin University

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  • Multiple Functions of the S-Phase Checkpoint Mediator

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There is mounting evidence that replication defects are the major source of spontaneous genomic instability in cells, and that S-phase checkpoints are the principal defense against such instability. The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase. In this review, the multiple functions and the regulation of the S-phase checkpoint mediator are discussed.

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