Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model

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  • MURATA Nakaba
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Applied Biological Chemistry, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
  • MURAKAMI Kazuma
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
  • OZAWA Yusuke
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
  • KINOSHITA Noriaki
    Immuno-Biological Laboratories Co., Ltd.
  • IRIE Kazuhiro
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
  • SHIRASAWA Takuji
    Department of Aging Control Medicine, Juntendo University Graduate School of Medicine
  • SHIMIZU Takahiko
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Applied Biological Chemistry, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology

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タイトル別名
  • Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model
  • Silymarin attenuated the amyloid v plaque burden and improved behavioral abnormalities in an Alzheimer s disease mouse model

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Alzheimer’s disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β-protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.

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