Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model
-
- MURATA Nakaba
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Applied Biological Chemistry, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
-
- MURAKAMI Kazuma
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
-
- OZAWA Yusuke
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
-
- KINOSHITA Noriaki
- Immuno-Biological Laboratories Co., Ltd.
-
- IRIE Kazuhiro
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
-
- SHIRASAWA Takuji
- Department of Aging Control Medicine, Juntendo University Graduate School of Medicine
-
- SHIMIZU Takahiko
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Applied Biological Chemistry, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
Bibliographic Information
- Other Title
-
- Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model
- Silymarin attenuated the amyloid v plaque burden and improved behavioral abnormalities in an Alzheimer s disease mouse model
Search this article
Description
Alzheimer’s disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β-protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.
Journal
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 74 (11), 2299-2306, 2010
Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282681456108800
-
- NII Article ID
- 10027561730
-
- NII Book ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- NDL BIB ID
- 10899929
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed