Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model
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- MURATA Nakaba
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Applied Biological Chemistry, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
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- MURAKAMI Kazuma
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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- OZAWA Yusuke
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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- KINOSHITA Noriaki
- Immuno-Biological Laboratories Co., Ltd.
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- IRIE Kazuhiro
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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- SHIRASAWA Takuji
- Department of Aging Control Medicine, Juntendo University Graduate School of Medicine
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- SHIMIZU Takahiko
- Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology Applied Biological Chemistry, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
書誌事項
- タイトル別名
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- Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model
- Silymarin attenuated the amyloid v plaque burden and improved behavioral abnormalities in an Alzheimer s disease mouse model
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説明
Alzheimer’s disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β-protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (11), 2299-2306, 2010
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456108800
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- NII論文ID
- 10027561730
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10899929
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可