Zinc Depletion Activates the Endoplasmic Reticulum-Stress Sensor Ire1 via Pleiotropic Mechanisms

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  • NGUYEN Thanh Sy Le
    Graduate School of Biological Sciences, Nara Institute of Science and Technology
  • KOHNO Kenji
    Graduate School of Biological Sciences, Nara Institute of Science and Technology
  • KIMATA Yukio
    Graduate School of Biological Sciences, Nara Institute of Science and Technology

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  • Zinc Depletion Activates the Endoplasmic Reticulum-Stress Sensor Ire1 <i>via</i> Pleiotropic Mechanisms

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Although zinc deficiency evokes the endoplasmic reticulum (ER)-stress response, the activating mechanism remains obscure. Here we show that in yeast cells, the ER-stress sensor Ire1 was activated upon zinc deficiency. ER-stressing stimuli activating Ire1 are known to include ER accumulation of unfolded proteins and membrane-lipid aberrancy. According to the findings presented here, zinc deficiency causes both types of abnormality.

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